U.S. Most cancers Statistics Working Group. United States Most cancers Statistics: Main Most cancers Instances and Deaths, All Races/Ethnicities, Male and Feminine, 2017. In: Atlanta: U.S. Division of Well being and Human Providers, Facilities for Illness Management and Prevention and Nationwide Most cancers Institute, 2020.
Siegel RL, Miller KD, Jemal A. Most cancers statistics, 2018. CA Most cancers J Clin. 2018;68:7–30.
Allegra CJ, Aberle DR, Ganschow P, Hahn SM, Lee CN, Millon-Underwood S, et al. NIH state-of-the-science convention assertion: prognosis and administration of ductal carcinoma in situ (DCIS). NIH Consens State—Sci statements. 2009;26:1–27.
Society AC Most cancers Details & Figures 2017. In: Particular Part: Uncommon Cancers in Adults: American Most cancers Society, Inc., 2017.
Duffy SW, Dibden A, Michalopoulos D, Offman J, Parmar D, Jenkins J, et al. Display detection of ductal carcinoma in situ and subsequent incidence of invasive interval breast cancers: a retrospective population-based research. Lancet Oncol. 2016;17:109–14.
Rios AC, Fu NY, Lindeman GJ, Visvader JE. In situ identification of bipotent stem cells within the mammary gland. Nature. 2014;506:322–7.
Villadsen R, Fridriksdottir AJ, Rønnov-Jessen L, Gudjonsson T, Rank F, LaBarge MA, et al. Proof for a stem cell hierarchy within the grownup human breast. J Cell Biol. 2007;177:87–101.
Visvader JE. Cells of origin in most cancers. Nature. 2011;469:314–22.
Visvader JE, Lindeman GJ. Most cancers stem cells: present standing and evolving complexities. Cell Stem Cell. 2012;10:717–28.
Gjorevski N, Nelson CM. Built-in morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol. 2011;12:581–93.
André F, Cortés J. Rationale for focusing on fibroblast progress issue receptor signaling in breast most cancers. Breast Most cancers Res Deal with. 2015;150:1–8.
Moerkens M, Zhang Y, Wester L, van de Water B, Meerman JH. Epidermal progress issue receptor signalling in human breast most cancers cells operates parallel to estrogen receptor α signalling and ends in tamoxifen insensitive proliferation. BMC Most cancers. 2014;14:283.
Friedmann-Morvinski D, Verma IM. Dedifferentiation and reprogramming: origins of most cancers stem cells. EMBO Rep. 2014;15:244–53.
Friedmann-Morvinski D, Bushong EA, Ke E, Soda Y, Marumoto T, Singer O, et al. Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Sci (N. Y, N. Y). 2012;338:1080–4.
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013;152:25–38.
Landsberg J, Kohlmeyer J, Renn M, Bald T, Rogava M, Cron M, et al. Melanomas resist T-cell remedy by inflammation-induced reversible dedifferentiation. Nature. 2012;490:412–6.
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704–15.
Helczynska Ok, Kronblad A, Jögi A, Nilsson E, Beckman S, Landberg G, et al. Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Most cancers Res. 2003;63:1441–4.
Ischenko I, Zhi J, Moll UM, Nemajerova A, Petrenko O. Direct reprogramming by oncogenic Ras and Myc. Proc Natl Acad Sci USA. 2013;110:3937–42.
Vermeulen L, De Sousa EMF, van der Heijden M, Cameron Ok, de Jong JH, Borovski T, et al. Wnt exercise defines colon most cancers stem cells and is regulated by the microenvironment. Nat Cell Biol. 2010;12:468–76.
Jögi A, Vaapil M, Johansson M, Påhlman S. Most cancers cell differentiation heterogeneity and aggressive habits in strong tumors. Ups J Med Sci. 2012;117:217–24.
Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F, et al. Poised chromatin on the ZEB1 promoter allows breast most cancers cell plasticity and enhances tumorigenicity. Cell. 2013;154:61–74.
Takahashi Ok, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and grownup fibroblast cultures by outlined components. Cell. 2006;126:663–76.
Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, et al. Regular and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci USA. 2011;108:7950–5.
Butner JD, Cristini V, Zhihui W. Growth of a 3 dimensional, multiscale agent-based mannequin of ductal carcinoma in situ. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Conf. 2017;2017:86–89.
Butner JD, Chuang YL, Simbawa E, Al-Fhaid AS, Mahmoud SR, Cristini V, et al. A hybrid agent-based mannequin of the creating mammary terminal finish bud. J Theor Biol. 2016;407:259–70.
Butner JD, Fuentes D, Ozpolat B, Calin GA, Zhou X, Lowengrub J, et al. A multiscale agent-based mannequin of ductal carcinoma in situ. IEEE Trans bio-Med Eng. 2020;67:1450–61.
Butner JD, Cristini V, Wang Z. Understanding ductal carcinoma in situ invasion utilizing a multiscale agent-based mannequin(). Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Conf. 2018;2018:5846–9.
Shehata M, Waterhouse PD, Casey AE, Fang H, Hazelwood L, Khokha R. Proliferative heterogeneity of murine epithelial cells within the grownup mammary gland. Commun Biol. 2018;1:111.
Paine I, Chauviere A, Landua J, Sreekumar A, Cristini V, Rosen J, et al. A geometrically-constrained mathematical mannequin of mammary gland ductal elongation reveals novel mobile dynamics inside the terminal finish bud. PLOS Computational Biol. 2016;12:e1004839–e1004839.
Dogra P, Butner JD, Ruiz Ramirez J, Chuang YL, Noureddine A, Jeffrey Brinker C, et al. A mathematical mannequin to foretell nanomedicine pharmacokinetics and tumor supply. Comput Struct Biotechnol J. 2020;18:518–31.
Dogra P, Ruiz-Ramirez J, Sinha Ok, Butner JD, Pelaez MJ, Rawat M, et al. Innate immunity performs a key function in controlling viral load in COVID-19: mechanistic insights from a whole-body an infection dynamics mannequin. ACS Pharmacol Transl Sci. 2021;4:248–65.
Wang Z, Birch CM, Sagotsky J, Deisboeck TS. Cross-scale, cross-pathway analysis utilizing an agent-based non-small cell lung most cancers mannequin. Bioinformatics. 2009;25:2389–96.
Wang Z, Bordas V, Deisboeck TS. Identification of vital molecular elements in a multiscale most cancers mannequin based mostly on the combination of Monte Carlo, resampling, and ANOVA. Entrance Physiol. 2011;2:35.
Wang Z, Deisboeck TS, Cristini V. Growth of a sampling-based world sensitivity evaluation workflow for multiscale computational most cancers fashions. IET Syst Biol. 2014;8:191–7.
Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, et al. Predicting breast most cancers response to neoadjuvant chemotherapy based mostly on tumor vascular options in needle biopsies. JCI Perception. 2019;4:1–12.e126518.
Butner JD, Wang Z, Elganainy D, Al Feghali KA, Plodinec M, Calin GA, et al. A mathematical mannequin for the quantification of a affected person’s sensitivity to checkpoint inhibitors and long-term tumour burden. Nat Biomed Eng. 2021;5:297–308.
Brocato TA, Coker EN, Durfee PN, Lin YS, Townson J, Wyckoff EF, et al. Understanding the connection between nanoparticle uptake and most cancers therapy efficacy utilizing mathematical modeling. Sci Rep. 2018;8:7538.
Dogra P, Ramirez JR, Butner JD, Pelaez MJ, Chung C, Hooda-Nehra A, et al. Translational modeling identifies synergy between nanoparticle-delivered miRNA-22 and standard-of-care medication in triple-negative breast most cancers. Pharm Res. 2022;39:511–28.
Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, et al. Lack of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion by altered adhesive and proteolytic perform. Breast Most cancers Res. 2017;19:33.
Yao Y, Wang C. Dedifferentiation: inspiration for devising engineering methods for regenerative medication. npj Regenerative Med. 2020;5:14.
Schymik B, Buerger H, Krämer A, Voss U, van der Groep P, Meinerz W, et al. Is there ‘development by grade’ in ductal invasive breast most cancers? Breast Most cancers Res Deal with. 2012;135:693–703.
Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and never from basal stem cells. Cell Stem Cell. 2010;7:403–17.
Guo Q, Li VZ, Nichol JN, Huang F, Yang W, Preston SEJ, et al. MNK1/NODAL signaling promotes invasive development of breast ductal carcinoma in situ. Most cancers Res. 2019;79:1646–57.
Xu Y, Lee DK, Feng Z, Xu Y, Bu W, Li Y, et al. Breast tumor cell-specific knockout of Twist1 inhibits most cancers cell plasticity, dissemination, and lung metastasis in mice. Proc Natl Acad Sci USA. 2017;114:11494–9.
Giebel B, Zhang T, Beckmann J, Spanholtz J, Wernet P, Ho AD, et al. Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their preliminary cell division. Blood. 2006;107:2146–52.
Gandhi A, Holland PA, Knox WF, Potten CS, Bundred NJ. Proof of great apoptosis in poorly differentiated ductal carcinoma in situ of the breast. Br J Most cancers. 1998;78:788–94.
Wagner BA, Venkataraman S, Buettner GR. The speed of oxygen utilization by cells. Free Radic Biol Med. 2011;51:700–12.