Sonntag, Juli 31, 2022
StartBiochemistryMiR-140 targets Wnt1 to inhibit the proliferation and improve drug sensitivity in...

MiR-140 targets Wnt1 to inhibit the proliferation and improve drug sensitivity in osteosarcoma cells




Wang Zhi

Foot and Ankle Surgical procedure Middle, Beijing Tongren Hospital of Capital Medical College, Beijing 100005, China


Qu Feng

Foot and Ankle Surgical procedure Middle, Beijing Tongren Hospital of Capital Medical College, Beijing 100005, China


Zhang Mingzhu

Foot and Ankle Surgical procedure Middle, Beijing Tongren Hospital of Capital Medical College, Beijing 100005, China

Corresponding Writer(s) : Zhang Mingzhu

michaelzhang120@hotmail.com

Mobile and Molecular Biology,
Vol. 68 No. 1: Difficulty 1

Summary

MicroRNAs (miRNAs) have been documented to perform otherwise in quite a few human cancers. Our examine deliberate to research the position of microRNA-140 (miR-140) and to determine its potential goal in osteosarcoma (OS) to foretell their mechanism in OS. The miR-140 was down-regulated in OS, and its excessive expression decreased MG63 cell proliferation. On the molecular stage, Wnt1 was a goal of miR-140, and its expression might be suppressed by miR-140. Moreover, miR-140 overexpression decreased drug resistance in OS cells handled by doxorubicin. Collectively, overexpression of miR-140 might inhibit human OS cell proliferation and should improve drug sensitivity by direct regulation of Wnt/β-catenin signaling.

Zhi, W. ., Feng, Q. ., & Mingzhu, Z. . (2022). MiR-140 targets Wnt1 to inhibit the proliferation and improve drug sensitivity in osteosarcoma cells. Mobile and Molecular Biology, 68(1), 140–146. https://doi.org/10.14715/cmb/2022.68.1.18

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