Corresponding Writer(s) : Zhang Mingzhu
Mobile and Molecular Biology,
Vol. 68 No. 1: Difficulty 1
MicroRNAs (miRNAs) have been documented to perform otherwise in quite a few human cancers. Our examine deliberate to research the position of microRNA-140 (miR-140) and to determine its potential goal in osteosarcoma (OS) to foretell their mechanism in OS. The miR-140 was down-regulated in OS, and its excessive expression decreased MG63 cell proliferation. On the molecular stage, Wnt1 was a goal of miR-140, and its expression might be suppressed by miR-140. Moreover, miR-140 overexpression decreased drug resistance in OS cells handled by doxorubicin. Collectively, overexpression of miR-140 might inhibit human OS cell proliferation and should improve drug sensitivity by direct regulation of Wnt/β-catenin signaling.
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